Print To PDF
Industrial Biotechnology Shaping Corn Biorefineries of the Future
Vijay Singh,1,2 Joel Stone,3 Jeffrey P. Robert,4 and Sundeep N. Vani5
© 2019 AACC International, Inc.
Bio-based markets, enabled by synthetic biology and increased emphasis on sustainability, are growing in the United States and around the world. Over the last five years, an exponential increase in investments in synthetic biology has been observed. Large amounts of renewable carbon in the form of fermentable sugars will be required to enable the production of next-generation biopolymer, biochemical, biofuel, and food products. In North America, sugars from corn (maize) will be the most abundant carbon source available to drive the industrial biotechnology engine. The demand for renewable carbon will improve stability in agricultural economies and support regional agricultural job creation. Traditional corn processing facilities are responding to this need by retrofitting their processing facilities to produce low-cost sugars or redirecting sugars from shrinking high-fructose corn syrup and dextrose markets to high-growth industrial biotechnology markets. However, there are still challenges that must be overcome to convert this opportunity into commercial reality. To succeed, new product and process development initiatives must meet economic, regulatory, quality, and other requirements within budget and time constraints. Translational research facilities that are specifically intended to accelerate commercialization and reduce the risk of utilizing new technologies will play a crucial role in realizing the opportunities offered by industrial biotechnology.
Trying to reach content?
View Full Article
if you don't have access, become a member
- Beale, A. Specialty chemicals—The search for stability and value in the 2016 global chemical industry. Published online at https://chemweek.com/CW/Document/77706/Specialty-chemicals-The-search-for-stability-and-value. Chem. Week, March 14, 2016.
- Biotechnology Innovation Organization. Renewable chemical platforms building the biobased economy. Ind. Biotechnol. 14:109, 2018.
- Bomgardner, M. The to-do list for ‘clean’ meat. C&EN 96:26, 2018.
- CB Insights. Our meatless future: How the $90b global meat market gets displaced. Published online at www.cbinsights.com/research/future-of-meat-industrial-farming. CB Information Services, Inc., New York, NY, 2019.
- Chinthapalli, R., Skoczinski, P., Carus, M., Baltus, W., de Guzman, D., Käb, H., Raschka, A., and Ravenstijn, J. Biobased building blocks and polymers—Global capacities, production and trends, 2018–2023. Ind. Biotechnol. 15:237, 2019.
- Cross, R. CRISPR’s breakthrough problem. C&EN 95:28, 2017.
- Deloitte. Opportunities for the fermentation-based chemical industry: An analysis of the market potential and competitiveness of north-west Europe. Published online at https://www2.deloitte.com/content/dam/Deloitte/nl/Documents/manufacturing/deloitte-nl-manufacturing-opportunities-for-the-fermentation-based-chemical-industry-2014.pdf. Deloitte, Netherlands, 2014.
- Grassini, P., Eskridge, K. M., and Cassman, K. G. Distinguishing between yield advances and yield plateaus in historical crop production trends. Nat. Commun. 4:2918, 2013.
- Jakel, N., Kwik, J., Franko, M., and Walen, A. Systems and methods for producing a sugar stream. U.S. patent US9777303B2, 2017.
- Jiang, W. Y., Bikard, D., Cox, D., Zhang, F., and Marraffini, L. A. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat. Biotechnol. 31:233, 2013.
- Lux Research. De-risking protein strategies using a systems approach: A novel analytical framework. Published online at https://members.luxresearchinc.com/research/report/17945. Lux Research, Inc., Boston, MA, 2015.
- National Academies of Sciences, Engineering, and Medicine. Industrialization of biology: A roadmap to accelerate the advanced manufacturing of chemicals. Available online at www.library.illinois.edu/proxy/go.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=26225395&site=eds-live&scope=site. National Academy of Sciences, Washington, DC, 2015.
- Oh, V. The new face of biobased: How performance enables sustainability in tomorrow’s products. Ind. Biotechnol. 13:5, 2017.
- Renewable Fuels Association. Powered with renewed energy: 2019 Ethanol industry outlook. RFA, Washington, DC, 2019.
- Schilling, C. Five ways biotech supports the transition to a more circular economy. Ind. Biotechnol. 15:234, 2019.
- Schmidt, C. These 98 synthetic biology companies raised $3.8 billion in 2018. Published online at https://synbiobeta.com/these-98-synthetic-biology-companies-raised-3-8-billion-in-2018. SynBioBeta.com, December 19, 2018.
- Selekman, J. A., Qiu, J., Tran, K., Stevens, J., Rosso, V., Simmons, E., Xiao, Y., and Janey, J. High-throughput automation in chemical process development. Annu. Rev. Chem. Biomol. Eng. 8:525, 2017.
- Zhaoqin, W., Vivek, S., Dien, B. S., and Vijay, S. High-conversion hydrolysates and corn sweetener production in dry-grind corn process. Cereal Chem. 95:302, 2018.